Defining ductal tissue

Defining dermal adipose tissue.

Here, we explore the evolution and development of skin-associated adipose tissue with the goal of establishing nomenclature for this tissue. Underlying the reticular dermis, a thick layer of adipocytes exists that encases mature hair follicles in rodents and humans. The association of lipid-filled cells with the skin is found in many invertebrate and vertebrate species. Historically, this layer...

Defining Contributions of Pancreatic Ductal and Acinar Cells to Tumorigenesis

The cellular origin of pancreatic tumors remains a vital topic for research to further our understanding of carcinogenesis. We currently do not know if cellular origin determines the phenotype of pancreatic tumors. Ninety percent of newly diagnosed pancreatic cancers are ductal adenocarcinomas (PDA). The majority of PDA are thought to originate from low-grade precursor tumors termed pancreatic ...

Defining intravenous recombinant tissue plasminogen activator failure.

Defining tissue resident vascular stem cells

Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma.

Tissue factor (TF) is a transmembrane glycoprotein that plays roles in the blood coagulation and intracellular signaling pathways, and has also been suggested to modulate the biological behavior of cancer cells. In order to examine the clinicopathologic significance of TF expression in pancreatic ductal adenocarcinoma, TF expression was determined by immunohistochemistry using a newly raised an...